| Day | Game | Visitor | Score | Home | Score | Overtime | Shootout | Game Details |
|---|---|---|---|---|---|---|---|---|
| 1 | 5 | Boston Bruins | 6 | Buffalo Sabres | 3 | - | - | Boxscore |
| 4 | 29 | Columbus Blue Jackets | 4 | Buffalo Sabres | 5 | - | - | Boxscore |
| 5 | 39 | Buffalo Sabres | 1 | Ottawa Senators | 4 | - | - | Boxscore |
| 9 | 63 | Buffalo Sabres | 5 | Montreal Canadiens | 2 | - | - | Boxscore |
| 11 | 85 | Buffalo Sabres | 5 | Pittsburgh Penguins | 4 | - | - | Boxscore |
| 14 | 97 | Seattle Kraken | 3 | Buffalo Sabres | 1 | - | - | Boxscore |
| 16 | 110 | Ottawa Senators | 5 | Buffalo Sabres | 4 | - | - | Boxscore |
| 18 | 126 | Vancouver Canucks | 2 | Buffalo Sabres | 3 | - | - | Boxscore |
| 20 | 144 | San Jose Sharks | 4 | Buffalo Sabres | 3 | True | True | Boxscore |
| 22 | 163 | Chicago Blackhawks | 1 | Buffalo Sabres | 3 | - | - | Boxscore |
| 25 | 178 | Tampa Bay Lightning | 1 | Buffalo Sabres | 4 | - | - | Boxscore |
| 28 | 209 | Buffalo Sabres | 4 | Anaheim Ducks | 3 | - | - | Boxscore |
| 29 | 217 | Buffalo Sabres | 5 | Los Angeles Kings | 3 | - | - | Boxscore |
| 32 | 233 | Buffalo Sabres | 3 | San Jose Sharks | 2 | - | - | Boxscore |
| 37 | 261 | New York Rangers | 2 | Buffalo Sabres | 4 | - | - | Boxscore |
| 39 | 277 | Buffalo Sabres | 4 | New York Islanders | 2 | - | - | Boxscore |
| 42 | 291 | Tampa Bay Lightning | 2 | Buffalo Sabres | 4 | - | - | Boxscore |
| 44 | 302 | Calgary Flames | 3 | Buffalo Sabres | 5 | - | - | Boxscore |
| 46 | 318 | New York Islanders | 5 | Buffalo Sabres | 3 | - | - | Boxscore |
| 48 | 333 | Montreal Canadiens | 3 | Buffalo Sabres | 2 | - | - | Boxscore |
| 49 | 336 | Buffalo Sabres | 3 | Ottawa Senators | 2 | - | - | Boxscore |
| 52 | 364 | Buffalo Sabres | 3 | New Jersey Devils | 2 | - | - | Boxscore |
| 54 | 377 | Colorado Avalanche | 3 | Buffalo Sabres | 1 | - | - | Boxscore |
| 57 | 392 | Buffalo Sabres | 6 | Philadelphia Flyers | 3 | - | - | Boxscore |
| 59 | 408 | Philadelphia Flyers | 3 | Buffalo Sabres | 4 | True | - | Boxscore |
| 60 | 416 | Buffalo Sabres | 3 | Toronto Maple Leafs | 8 | - | - | Boxscore |
| 63 | 431 | Buffalo Sabres | 6 | Carolina Hurricanes | 1 | - | - | Boxscore |
| 66 | 455 | Minnesota Wild | 6 | Buffalo Sabres | 1 | - | - | Boxscore |
| 67 | 468 | Buffalo Sabres | 5 | Pittsburgh Penguins | 3 | - | - | Boxscore |
| 70 | 480 | Boston Bruins | 3 | Buffalo Sabres | 2 | - | - | Boxscore |
| 73 | 503 | Buffalo Sabres | 2 | Winnipeg Jets | 3 | - | - | Boxscore |
| 75 | 521 | Buffalo Sabres | 4 | Chicago Blackhawks | 3 | True | - | Boxscore |
| 78 | 536 | Buffalo Sabres | 4 | Washington Capitals | 3 | - | - | Boxscore |
| 80 | 552 | Pittsburgh Penguins | 3 | Buffalo Sabres | 4 | - | - | Boxscore |
| 81 | 561 | Buffalo Sabres | 2 | New Jersey Devils | 6 | - | - | Boxscore |
| 83 | 573 | Buffalo Sabres | 2 | New York Rangers | 3 | True | True | Boxscore |
| 86 | 599 | Buffalo Sabres | 3 | St. Louis Blues | 1 | - | - | Boxscore |
| 88 | 611 | Buffalo Sabres | 3 | Carolina Hurricanes | 4 | - | - | Boxscore |
| 89 | 623 | Nashville Predators | 4 | Buffalo Sabres | 2 | - | - | Boxscore |
| 91 | 631 | Detroit Red Wings | 3 | Buffalo Sabres | 4 | - | - | Boxscore |
| 93 | 643 | Buffalo Sabres | 5 | Boston Bruins | 3 | - | - | Boxscore |
| 95 | 662 | Montreal Canadiens | 2 | Buffalo Sabres | 5 | - | - | Boxscore |
| 97 | 679 | Utah HC | 0 | Buffalo Sabres | 1 | - | - | Boxscore |
| 99 | 696 | Buffalo Sabres | 3 | Colorado Avalanche | 5 | - | - | Boxscore |
| 101 | 711 | Buffalo Sabres | 3 | Vegas Golden Knights | 6 | - | - | Boxscore |
| 102 | 721 | Buffalo Sabres | 6 | Utah HC | 2 | - | - | Boxscore |
| 105 | 736 | Columbus Blue Jackets | 3 | Buffalo Sabres | 5 | - | - | Boxscore |
| 107 | 749 | Toronto Maple Leafs | 4 | Buffalo Sabres | 3 | True | True | Boxscore |
| 109 | 773 | Buffalo Sabres | 0 | New York Rangers | 0 | - | - | |
| 114 | 782 | Dallas Stars | 0 | Buffalo Sabres | 0 | - | - | |
| 118 | 804 | St. Louis Blues | 0 | Buffalo Sabres | 0 | - | - | |
| 121 | 824 | Los Angeles Kings | 0 | Buffalo Sabres | 0 | - | - | |
| 123 | 838 | Florida Panthers | 0 | Buffalo Sabres | 0 | - | - | |
| 125 | 853 | Buffalo Sabres | 0 | Minnesota Wild | 0 | - | - | |
| 127 | 866 | Anaheim Ducks | 0 | Buffalo Sabres | 0 | - | - | |
| 129 | 884 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 131 | 900 | Buffalo Sabres | 0 | Columbus Blue Jackets | 0 | - | - | |
| 133 | 920 | Carolina Hurricanes | 0 | Buffalo Sabres | 0 | - | - | |
| 135 | 928 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 137 | 945 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - | |
| 139 | 960 | Vegas Golden Knights | 0 | Buffalo Sabres | 0 | - | - | |
| 140 | 972 | Winnipeg Jets | 0 | Buffalo Sabres | 0 | - | - | |
| 143 | 990 | Buffalo Sabres | 0 | Toronto Maple Leafs | 0 | - | - | |
| 144 | 1000 | Buffalo Sabres | 0 | Nashville Predators | 0 | - | - | |
| 146 | 1009 | Edmonton Oilers | 0 | Buffalo Sabres | 0 | - | - | |
| 149 | 1031 | Detroit Red Wings | 0 | Buffalo Sabres | 0 | - | - | |
| 151 | 1045 | New York Islanders | 0 | Buffalo Sabres | 0 | - | - | |
| 153 | 1059 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 155 | 1081 | Buffalo Sabres | 0 | Seattle Kraken | 0 | - | - | |
| 156 | 1093 | Buffalo Sabres | 0 | Vancouver Canucks | 0 | - | - | |
| 158 | 1104 | Buffalo Sabres | 0 | Edmonton Oilers | 0 | - | - | |
| 161 | 1133 | Buffalo Sabres | 0 | Calgary Flames | 0 | - | - | |
| 164 | 1148 | Ottawa Senators | 0 | Buffalo Sabres | 0 | - | - | |
| 166 | 1164 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 167 | 1171 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 170 | 1189 | Washington Capitals | 0 | Buffalo Sabres | 0 | - | - | |
| 173 | 1211 | Philadelphia Flyers | 0 | Buffalo Sabres | 0 | - | - | |
| 175 | 1228 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 177 | 1246 | Buffalo Sabres | 0 | Dallas Stars | 0 | - | - | |
| 179 | 1255 | Washington Capitals | 0 | Buffalo Sabres | 0 | - | - | |
| 181 | 1273 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 183 | 1290 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - |